Neural basis for improgan antinociception
نویسندگان
چکیده
منابع مشابه
Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor.
Many analgesic drugs, including μ-opioids, cannabinoids, and the novel nonopioid analgesic improgan, produce antinociception by actions in the rostral ventromedial medulla (RVM). There they activate pain-inhibiting neurons, termed "OFF-cells," defined by a nociceptive reflex-related pause in activity. Based on recent functional evidence that neuronal P450 epoxygenases are important for the cent...
متن کاملPhysiological Basis for Inhibition of Morphine and Improgan Antinociception by Cc12, a P450 1 Epoxygenase Inhibitor 2
18 Many analgesic drugs, including mu-opioids, cannabinoids, and the novel non-opioid 19 analgesic improgan, produce antinociception by actions in the rostral ventromedial medulla 20 (RVM). There they activate pain-inhibiting neurons, termed " OFF-cells " , defined by a 21 nociceptive reflex-related pause in activity. Based on recent functional evidence that 22 neuronal P450 epoxygenases are im...
متن کاملImprogan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.
Improgan is an analog of the H(2) antagonist cimetidine that does not act on known histamine receptors, but induces highly effective analgesia in rodents following intracerebroventricular (icv) administration. Since the mechanism of action of this compound remains unknown, improgan analgesia was characterized presently with the tail immersion nociceptive test in mutant mice lacking either the m...
متن کاملInhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors.
Improgan, a nonopioid antinociceptive agent, activates descending, pain-relieving mechanisms in the brain stem, but the receptor for this compound has not been identified. Because cannabinoids also activate nonopioid analgesia by a brain stem action, experiments were performed to assess the significance of cannabinoid mechanisms in improgan antinociception. The cannabinoid CB(1) antagonist N-(p...
متن کاملNeural basis for unique hues
p = 0.38, respectively). Moreover, analyses of only high confidence states yielded similar results as when highand lowconfidence states were pooled (see Supplemental Data). Together with the numerically large and robust difference between expected and unexpected percepts in the test phase, these observations speak to a true perceptual bias rather than a mere response bias. Our work shows that e...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2010
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.05.042